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Inhibition of Orai2/STIM1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Orai1/STIM1 (unknown origin)
Inhibition of human STIM1/Orai3 expressed in HEK293 cells assessed as reduction in Orai3 current by electrophysiological method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human STIM1/Orai1 expressed in HEK293 cells assessed as reduction in Orai1 current by electrophysiological method
Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 300 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 100 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control
Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual patch clamp based electrophysiological method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 2 uM by whole cell patch clamp electrophysiological method
Inhibition of STIM/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in thapsigargin-induced Ca2+ influx at 10 uM in presence of Ca2+ by whole cell patch clamp method
Assay data:2 Active, 2 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in slope of calcium entry at 10 uM relative to control
Assay data:9 Active, 9 Tested
Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in AUC of calcium entry at 10 uM relative to control
Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in peak amplitude of calcium entry at 10 uM relative to control
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in peak amplitude of calcium entry at 10 uM relative to control
Assay data:10 Active, 10 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in calcium entry AUC at 10 uM relative to control
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response at 10 uM relative to control
Assay data:42 Tested
Inhibition of ORAI/STIM1 in thapsigargin treated rat RBL2H3 cells assessed as reduction in store-operated calcium entry after 5 mins by fura-2-AM dye based assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of EGFP-tagged Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in BAPTA-induced calcium release activated calcium channel currents at 2 uM after 30 to 60 mins by whole cell patch clamp method
Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 800 secs by Fluo-4 AM-based fluorometric assay relative to control
Assay data:1 Active, 2 Tested
Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 800 secs by Fluo-4 AM-based fluorometric assay relative to control
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