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Agonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 10 nM alpha-MSH by split luciferase cAMP sensor dynamic assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Agonist activity at human MC1R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation at 10 uM by fluorescence based analysis relative to control
Assay data:8 Tested
Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cells by competitive binding assay
Assay data:12 Active, 13 Activity ≤ 1 µM, 13 Tested
Agonist activity at human MC1R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis
Assay data:7 Active, 8 Activity ≤ 1 µM, 8 Tested
Agonist activity at human MC1R assessed as increase in alpha-MSH induced cAMP level at 10 uM relative to control
Intrinsic agonist activity at human MC1R assessed as increase in alpha-MSH induced cAMP level by measuring maximum response relative to control
Assay data:10 Tested
Agonist activity at human MC1R assessed as increase in alpha-MSH induced cAMP level
Assay data:11 Active, 7 Activity ≤ 1 µM, 17 Tested
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of beta-arrestin2 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of beta-arrestin1 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of G15 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of G14 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of G13 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of G12 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of G11 signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of Gq signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of Gs signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of Gz signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
Agonist activity at human MC4R expressed in HEK293SL cells assessed as activation of GoB signaling pathway at 1 uM measured upto 25 mins in presence of alpha-MSH by BRET assay
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