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Inhibition of Cathepsin C (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of human Cathepsin C using Gly- L -Phe-p-nitroanilide.HCl as substrate
Assay data:1 Tested
Inhibition of human Cathepsin C using Gly-Phe-paranitroanilide as substrate incubated for 12 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human Cathepsin C using Gly-Phe-AMC as substrate assessed as kobs/[I]
Assay data:2 Tested
Inhibition of human Cathepsin C using Ala-4-[ 125 I]Phe-DMK as substrate preincubated for 30 mins followed by substrate addition measured after 6 to 24 hrs
Inhibition of human Cathepsin C using Z-Arg-Arg-AM as substrate at 3 microM relative to control
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
In Vitro DPP1 Enzyme Activity Assay from US Patent US11807635: "Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof"
Assay data:12 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescence Assay for Recombinant Human (RH) DPP1 from US Patent US20230278969: "CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS"
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
Fluorescence Assay for Recombinant Human (RH) DPP1 from US Patent US11680049: "Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors"
Fluorescence assay for recombinant human (RH) DPP1 from US Patent US11673871: "Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors"
Assay data:35 Active, 35 Activity ≤ 1 µM, 35 Tested
Fluorescence Assay for Recombinant Human (RH) DPP1 from US Patent US11667615: "Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors"
Assay data:36 Active, 36 Activity ≤ 1 µM, 36 Tested
Fluorescence Assay for Recombinant Human (RH) DPP from US Patent US11655221: "Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors"
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of cathepsin G at 1 uM treated for 12 hrs by Western blotting analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of protease 3 at 1 uM treated for 12 hrs by Western blotting analysis
Binding affinity to Cathepsin C in human U-937 cells assessed as increase in thermal stability measured at 52 degC after 4 hrs by cellular thermal shift assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of cathepsin G at 1 uM treated for 48 hrs by Western blotting analysis
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of protease 3 at 1 uM treated for 48 hrs by Western blotting analysis
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of neutrophil elastase at 1 uM treated for 48 hrs by Western blotting analysis
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of neutrophil elastase at 1 uM treated for 12 hrs by Western blotting analysis
Inhibition of Cathepsin C in C57BL/6 mouse Bone marrow cells assessed as reduction of NSPs stability by measuring stability of Cat G at 1 uM treated for 6 hrs by Western blotting analysis
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