Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
RAF1 Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of c-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of RAF1 (unknown origin) at 10 uM using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay relative to control
Assay data:4 Tested
Inhibition of RAF1 (unknown origin) using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of cRAF1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant GST-fused cRAF expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:1 Active, 1 Tested
Inhibition of KRAS (unknown origin) to CRAF (unknown origin) protein protein interaction
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of RAF1 (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
Inhibition of human partial length wild type c-RAF (I330/T640) expressed in bacterial system at 1 uM by KINOMEscan analysis relative to control
Stabilization of 14-3-3 eta (unknown origin)/ c-Raf (unknown origin)
Inhibition of c-Raf (unknown origin)
Assay data:3 Tested
Inhibition of human CRAF incubated for 40 mins by scintillation counter analysis
The stabilization effect of I-2 and avutometinib (VS6766) on MEK1-CRAF complex were tested and compared using SPR. from US Patent US20230382863: "MEK INHIBITORS AND USES THEREOF"
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
AlphaLISA Assay from US Patent US20230382863: "MEK INHIBITORS AND USES THEREOF"
Assay data:9 Active, 9 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
RAF Inhibition Assay from US Patent US20230312556: "ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:85 Active, 1 Activity ≤ 1 nM, 87 Activity ≤ 1 µM, 87 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Assay from US Patent US11667634: "Inhibitors of RAF kinases"
Assay data:65 Active, 65 Activity ≤ 1 µM, 65 Tested
LanthaScreen Eu kinase binding assay from US Patent USRE49361: "Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers"
Assay data:21 Active, 3 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Evaluation of RAF Kinase Activity from US Patent US11492357: "Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on