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Neuropeptide Y Y1 Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:11 Active, 1 Activity ≤ 1 µM, 1098 Tested
Induction of internalization of C-terminal EYFP-tagged human Y1R transfected in HEK293 cells assessed as disappearance of green cell surface fluorescence at 100 nM measured after 1 hr by Hoechst33342 staining based live-cell microscopic analysis
Assay data:5 Active, 5 Tested
Induction of internalization of C-terminal EYFP-tagged human Y2R transfected in HEK293 cells assessed as disappearance of green cell surface fluorescence at 100 nM measured after 1 hr by Hoechst33342 staining based live-cell microscopic analysis
Assay data:1 Active, 1 Tested
Induction of internalization of C-terminal EYFP-tagged human Y1R transfected in HEK293 cells assessed as increase in fluorescence in intracellular vesicles at 100 nM measured after 1 hr by Hoechst33342 staining based live-cell microscopic analysis
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Displacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Neuropeptide Y Y1 Eurofins-Panlabs radioligand binding assay
Y1 (h) CEREP panel
Y1/HU Eurofins SafetyScreen44 (BI)
Assay data:13 Tested
Y1 (h) Eurofins-Cerep binding assay
Assay data:2 Tested
PRESTO-Tango GPCRome screening (NPY1R)
Y1 (h) CEREP ligand profiling
Y1/HU Eurofins-Panlabs selectivity data (BI)
Y1/HUM Cerep selectivity data (BI)
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