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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000336a TIE1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b TIE1
Affinity Biochemical interaction (KdELECT (DiscoverX)) EUB0000713a TIE1
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000713a TIE1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000703a TIE1
Binding affinity to TIE1 (unknown origin) assessed as dissociation constant by competition binding assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
TIE1 DiscoveRx kinase panel
Binding affinity to wild-type human partial length TIE1 (T819 to A1138 residues) expressed in bacterial expression system by Kinomescan method
KinomeScan assay: inhibition of TIE1
Assay data:2 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
KINOMEScan (DiscoveRx Corp) with TIE1
Inhibition of TIE1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human TIE1 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human TIE1 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human TIE1 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of wild-type human partial length TIE1 (T819 to A1138 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to wild-type human partial length TIE1 (T819 to A1138 residues) expressed in bacterial expression system by Kinomescan method relative to control
Inhibition of human partial length TIE1 (T819 to A1138 residues) expressed in bacterial expression system assessed as residual activity at 10 uM by kinome scan method relative to control
Inhibition of TIE1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luciferase reporter gene assay
Assay data:3 Tested
Inhibition of human TIE1
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