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Binding affinity towards human ESR2 in an in vitro cell free assay measured by fluorescence polarization method
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 287 Tested
SummaryRelated BioAssays by Target
Binding affinity to Estrogen receptor beta (unknown origin) at 1 uM by displacement assay relative to control
Assay data:1 Tested
Binding affinity to estrogen receptor beta LBD (unknown origin) expressed in yeast cells co-expressing YFP assessed as fold change in fluorescence at 10 uM incubated for 15 hrs in dark by fluorescence based UV-vis spectrophotometric analysis
Assay data:1 Active, 5 Tested
Displacement of Fluormone ES2 Green from ERbeta (unknown origin) at 30 uM by TR-FRET based competitive binding assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant ERbeta expressed in baculovirus expression system measured after 20 mins by fluorescent polarisation Assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Relative binding affinity to human ERbeta measured after 2 hrs by competitive fluorometric binding assay relative to estradiol
Assay data:24 Tested
Antagonist activity at ERbeta expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of di-arylpropionitrile by luciferase reporter gene assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 8 Tested
Agonist activity at estrogen receptor beta (unknown origin)
Displacement of [3H]-estradiol from recombinant full-length human estrogen beta receptor expressed in baculovirus infected insect cells incubated overnight by liquid scintillation counting analysis
Assay data:3 Tested
Binding affinity to human recombinant ERbeta by competitive fluorometric binding assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 18 Tested
Binding affinity to ERbeta (unknown origin) at 10 uM by Lanthascreen TR-FRET assay
Binding affinity to ERbeta (unknown origin) at 10 uM by Lanthascreen TR-FRET assay relative to control
Relative binding affinity to ERbeta (unknown origin)
Assay data:19 Tested
Antagonist activity at ERbeta (unknown origin)
Assay data:19 Active, 1 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Modulation of ER-beta (unknown origin)
Displacement of EL red from human full-length ER-beta expressed in baculovirus expression system incubated for 2 hrs by fluorescence polarization assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Agonist activity at human ER-beta transfected in HEC-1 cells assessed as transcriptional activation incubated for 24 hrs by dual luciferase reporter assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at ER-beta (unknown origin)
Agonist activity at human ER-beta ligand binding domain transfected in African green monkey COS-7 cells incubated for overnight by Dual-Glo luciferase assay
Agonist activity at human ER-beta transfected in African green monkey COS-7 cells measured after 24 hrs by Steady-Glo luciferase assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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