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Summary
Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
Inhibition of IKKa (unknown origin) at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (Kinase Panel (competition binding assay)) EUB0000589aTFA IKBKB
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000749a CHUK
SummaryRelated BioAssays by Target
Selectivity interaction (Enzymatic assay) EUB0000624a IKBKB
Selectivity interaction (Enzymatic assay) EUB0000624a CHUK
Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b CHUK
Affinity Biochemical interaction (Competition binding assay) EUB0000589aTFA IKBKB
Affinity Phenotypic Cellular interaction (Immunoblotting (inhibition of CHUK phosphorylation in THP-1 cells)) EUB0000589aTFA IKBKB
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of IKKbeta (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:3 Tested
Inhibition of human full length recombinant IKKalpha assessed as residual activity at 1 uM using peptide as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
Inhibition of recombinant human full length IKKbeta assessed as residual activity at 1 uM using peptide as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
Inhibition of human IKKbeta assessed as residual activity at 30 uM relative to control
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