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Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human RAD52 assessed as reduction in DNA annealing using tailed ds-DNA 337-F/1337-BHQ1 by fluorescence-quenching assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mins by fluorescence polarization assay
Assay data:10 Active, 10 Tested
Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mins by high-throughput fluorescence polarization assay relative to control
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RAD52 in hTERT-immortalized wild-type human GM01604 fibroblasts assessed as cell death at 1 uM relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of RAD52 in checkpoint deficient HU-treated in hTERT-immortalized wild-type human GM01604 fibroblasts assessed as potentiation of HU-induced cell death at 1 uM by Live/Dead assay relative to control
Binding affinity to RAD52 (unknown origin) by water-logsy NMR method
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-dsDNA interaction by FRET assay
Inhibition of RAD52 in hTERT-immortalized wild-type human GM01604 fibroblasts in presence of BRCA2 siRNA NA RAD52 siRNA assessed as potentiation of HU-induced cell death by Live/Dead assay relative to control
Inhibition of RAD52 in hTERT-immortalized wild-type human GM01604 fibroblasts with BRCA2 knockdown assessed as potentiation of HU and UCN01-induced cell death by Live/Dead assay relative to control
Inhibition of RAD52 in hTERT-immortalized wild-type human GM01604 fibroblasts with MUS81 knockdown assessed as potentiation of HU and UCN01-induced cell death by Live/Dead assay
Inhibition of RAD52 in checkpoint deficient in hTERT-immortalized wild-type human GM01604 fibroblasts assessed as decrease in MUS81/EME1/RAD52-dependent DSB formation by measuring mean tail moment in presence of UNC01 in presence of RAD52 siRNA by neutral comet assay
Assay data:2 Active, 2 Tested
Inhibition of RAD52 in checkpoint deficient HU-treated in hTERT-immortalized wild-type human GM01604 fibroblasts assessed as decrease in MUS81/EME1/RAD52-dependent DSB formation by measuring mean tail moment at 500 nM in presence of UNC01 by neutral comet assay
Inhibition of RAD52 in checkpoint deficient HU-treated in hTERT-immortalized wild-type human GM01604 fibroblasts assessed as inhibiting RAD52-MUS81-dependent DSBs at stalled replication forks in presence of UNC01 by neutral comet assay
Inhibition of RAD52 in checkpoint deficient HU-treated in hTERT-immortalized wild-type human GM01604 fibroblasts assessed as decrease in MUS81/EME1/RAD52-dependent DSB formation by measuring mean tail moment in presence of UNC01 by neutral comet assay
Assay data:2 Tested
Binding affinity to RAD52 (unknown origin) at 40 uM by water-logsy NMR method
Binding affinity to RAD52 (unknown origin) at 20 uM by water-logsy NMR method
Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA in presence of 0.01% Triton-X100 by FRET assay
Induction of protein aggregation of RAD52 (unknown origin) by dynamic light scattering assay
Effect on oligomeric ring of RAD52 (unknown origin) by dynamic light scattering assay
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