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Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CYP1A2 (unknown origin)
Assay data:3 Tested
Reversible inhibition of CYP1A2 in human liver microsomes assessed as residual activity at 5 uM using phenacetin as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Assay data:4 Tested
Inhibition of human CYP1A2
Assay data:1 Active, 2 Tested
Inhibition of CYP1A2 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC/MS/MS analysis
Assay data:1 Active, 1 Tested
Induction of CYP1A2 in human hepatocytes
Inhibition of recombinant CYP1A1 (unknown origin) assessed as decrease in EROD activity using 7-ethoxyresorufin as substrate upto 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry
Assay data:6 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:11 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 50 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 10 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:8 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 5 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 1 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:10 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 0.1 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 0.01 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Substrate activity at CYP1A1 in human liver microsomes assessed as metabolite formation at 1 mM preincubated for 10 mins followed by NADPH and CYP1A1 inhibitor, alpha-naphthoflavone addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Assay data:2 Tested
Substrate activity at CYP1A1 in human liver microsomes assessed as metabolite formation at 1 mM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Substrate activity at CYP1A1 in human liver microsomes assessed as hydroxylated metabolite formation with deuterated molecular ion at m/z 265.10940 at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by HDX LC/MS spectral analysis
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