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Inhibition of KIT (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of KIT (unknown origin) assessed as residual activity at 1 uM preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay relative to control
Assay data:1 Tested
Inhibition of KIT (unknown origin) at 1 uM relative to control
Inhibition of cKIT (unknown origin) by Ambit kinase assay
Assay data:4 Tested
Inhibition of KIT K642E mutant (unknown origin) autophosphorylation expressed in human GIST882 cells by ELISA-based assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant GST-fused c-KIT expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:2 Tested
Inhibition of cKIT (unknown origin)
Inhibition of c-Kit (unknown origin)
Inhibition of KIT D816V mutant (unknown origin)
Inhibition of KIT T670I mutant (unknown origin)
Inhibition of wild type KIT (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of KIT (unknown origin) in presence of ATP
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Biological Assay from US Patent US20230312583: "1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS"
Assay data:21 Active, 11 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Measurement of c-Abl1, c-Abl2 and c-Kit IC50 Values from US Patent US11725005: "Compositions and methods for inhibiting kinases"
Assay data:43 Active, 43 Activity ≤ 1 µM, 43 Tested
c-Kit Kinase Assay from US Patent US11679110: "Methods of treating disorders using CSF1R inhibitors"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
Kinase Activity Assay from US Patent US11591328: "Highly active CSF1R inhibitor compound"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000306b KIT
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b KIT
Assay data:1 Active, 1 Tested
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