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Binding affinity to wild type human CXCR2 assessed as dissociation constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryRelated BioAssays by Target
Inhibition of wild type CXCR2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at CXCR2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at CXCR1 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human CXCR2-mediated chemotaxis expressed in mouse BaF3 cells
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human CXCR1
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to human CXCR2 assessed as dissociation constant incubated for 6 to 24 hrs by radioligand binding assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human CXCR1 assessed as dissociation constant incubated for 6 to 24 hrs by radioligand binding assay
Binding affinity to human CXCR2 expressed in human U87 cells assessed as inhibition of CXCL8 AF647-induced calcium response incubated for 10 mins followed by addition of CXCL8 AF647 measured by FLIPR Tetra system method
Assay data:7 Active, 5 Activity ≤ 1 µM, 16 Tested
Binding affinity to human CXCR2 expressed in human U87 cells assessed as inhibition of CXCL8 AF647-binding incubated for 15 mins followed by addition of CXCL8 AF647 measured after 30 mins by flow cytometry analysis
Assay data:9 Active, 6 Activity ≤ 1 µM, 16 Tested
Chemokine CXCR2 (IL-8RB) Eurofins-Panlabs radioligand binding assay
Assay data:1 Tested
IL-8B (h) (CXCR2) CEREP panel
Inhibition of human CXCR2 at 10 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human CXCR1 at 10 uM relative to control
Antagonist activity against CXCR2 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CXCR2 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Antagonist activity against CXCR1 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CXCR1 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
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