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Modulation of human SMN2 level in NSC34 cells assessed as fold change by ELISA
Assay data:6 Active, 7 Activity ≤ 1 µM, 13 Tested
SummaryRelated BioAssays by Target
Modulation of human SMN2 level in NSC34 cells by ELISA
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of survival motor neuron protein in mouse C2C12 cells assessed as reduction in phospho-sites occupancy at 4 uM after 5 hrs by SILAC based LC-MS/MS analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of SMN protein in human SMA-derived fibroblasts after 48 hrs by HTRF assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter assessed as additive effect on SMN stabilization in presence of 0.1: 0.3 to 10:30 ratio of LDN-76070 to compound after 24 hrs by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter assessed as additive effect on SMN stabilization in presence of 0.1: 0.1 to 10:10 ratio of LDN-75654 to compound after 24 hrs by luciferase reporter gene assay
Stabilization of human luc fused SMN protein expressed in HEK293 cells at 10 uM after 24 hrs in presence of 10 uM cycloheximide by luciferase reporter gene assay
Assay data:4 Active, 4 Tested
Stabilization of human SMN protein expressed in HEK293 cells at 10 to 30 uM after 24 hrs by luciferase reporter gene assay
Stabilization of SMN protein in 3814T fibroblasts derived from human SMA patient assessed as increase in SMN protein level at 2 uM after 48 hrs by SDS-PAGE and immunoblot
Assay data:2 Tested
Stabilization of SMN protein in 3814T fibroblasts derived from human SMA patient assessed as increase in SMN protein level after 48 hrs by SDS-PAGE and immunoblot
Stabilization of SMN protein in HEK293 cells assessed as increase in SMN protein half life at 10 uM by pulse-chase experiment
Assay data:1 Active, 2 Tested
Stabilization of SMN protein in 3813T fibroblasts derived from human SMA patient assessed as increase in SMN protein level at 2 uM after 48 hrs by by SDS-PAGE and immunoblot
Stabilization of SMN protein in 3813T fibroblasts derived from human SMA patient assessed as increase in SMN protein level after 48 hrs by SDS-PAGE and immunoblot
Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assay relative to control
Assay data:43 Tested
Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assay
Assay data:30 Active, 12 Activity ≤ 1 µM, 43 Tested
Binding affinity to survival motor neuron protein in human INA-6 cells after 3 hrs by nanoLC-MS/MS method
Assay data:2 Active, 2 Tested
Activation of SMN in human fibroblast cells obtained from type 1 SMA patients assessed as protein punctuate bodies per 100 nuclei at 37 to 1000 nM relative to control
Activation of SMN in human fibroblast cells obtained from type 1 SMA patients assessed as protein punctuate bodies per 100 nuclei at 37 nM relative to control
Activation of SMN expressed in HEK293 cells by SMN2-promotor driven luciferase reporter gene assay
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