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Antagonist activity at CXCR6 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Binding affinity to CXCR6 (unknown origin) at 10 uM by radioligand binding assay
Assay data:1 Tested
Antagonist activity against CXCR6 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity against CXCR6 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
PRESTO-Tango GPCRome screening (CXCR6)
Antagonist activity at human Gi/G0-coupled CXCR6 assessed as inhibition of CXCL16-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CXCL16 stimulation and measured after 90 to 180 mins by pathhunter assay
Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay
Assay data:2 Tested
Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay relative to control
Assay data:61 Tested
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
Assay data:25 Active, 7 Activity ≤ 1 µM, 61 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay relative to control
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
Assay data:39 Active, 25 Activity ≤ 1 µM, 61 Tested
Antagonist activity at human CXCR6 at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins by cAMP assay
Agonist activity at CXCR6 (unknown origin)
Human CXCR6 (Chemokine receptors)
Assay data:1 Active, 1 Tested
Inhibition of CXCR6 (unknown origin) at 10 uM relative to control
Binding affinity to CXCR6 (unknown origin) at 10 uM by radioligand displacement assay
Antagonist activity at CXCR6 (unknown origin) assessed as inhibition of calcium flux at 10 uM
Antagonist activity at CXCR6 (unknown origin) assessed as inhibition of chemotaxis at 10 uM
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