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Inhibition of CypC (unknown origin)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of CypA (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to CypA (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Surface Plasmon Resonance (SPR) Assay from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Isothermal Titration Calorimetry (ITC) from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:8 Active, 4 Activity ≤ 1 µM, 21 Tested
Inhibition of CypA (unknown origin) upto 20 uM
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CypA (unknown origin) assessed as inhibition constant by isomer specific proteolysis assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to His6-tagged CypA (unknown origin) expressed in Escherichia coli BL21 (DE3) incubation at 1 hr by multimode plate reader
Assay data:6 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Surface Plasmon Resonance Assay from Article 10.1021/cc0501561: "Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay."
Assay data:10 Active, 5 Activity ≤ 1 µM, 16 Tested
PPIase Assay from Article 10.1021/bi9007287: "Isoform-specific inhibition of cyclophilins."
Assay data:4 Active, 2 Activity ≤ 1 µM, 9 Tested
PPIase Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
ESI-MS Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:6 Tested
Surface Plasmon Resonance (SPR) Assay from US Patent US9566312: "Cyclic peptides and use as medicines"
Assay data:105 Active, 77 Activity ≤ 1 nM, 105 Activity ≤ 1 µM, 105 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Protease-Free PPIase Assay from US Patent US10077289: "Cyclosporins modified on the MeBmt sidechain by heterocyclic rings"
Assay data:38 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 38 Tested
Binding affinity to Cyclophilin A (unknown origin) by surface plasmon resonance analysis
Assay data:1 Active, 1 Tested
Inhibition of PPIA (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assay
Assay data:1 Tested
Inhibition of C-terminal His6-tagged CypA (unknown origin) expressed in Escherichia coli C41(DE3) using Suc-Ala-Ala-Cis-Pro-Phe-pNA as substrate by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
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