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Inhibition of human Cav3.2 at 10 uM relative to control by Electrophysiological QPatch assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as slope factor at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = 5.3 +/- 0.6mV)
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as V1/2 at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = -65.6 +/- 3.1mV)
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as reduction inactivation time constant transient current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as activation time constant transient current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as increase in recovery time at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = 514.5 +/- 37.8ms)
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as slope factor at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = 5.2 +/- 0.2No_unit)
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as V1/2 at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = -64.8 +/- 1.3mV)
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as inactivation time constant transient current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as activation time constant transient current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as cell capacitance at 1 to 50 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as reduction in volatage induced peak current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Cav3.2 (unknown origin) stably transfected in HEK293 cells assessed as volatage induced T-type Ca2+ current at 1 to 50 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Voltage-dependent T-type calcium channel (unknown origin) by HTS assay
Effect on rat Cav3.3 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Inhibition of Cav3.3 subunit 1alpha-l(unknown origin) stably transfected in HEK293 cells measured by FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human Cav3.2 at 100 uM by Qpatch electrophysiological assay
Inhibition of Cav3.2 (unknown origin) at holding potential (Vh) -80 mV and measured by whole-cell voltage-camp assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Cav3.1 (unknown origin) at holding potential (Vh) -80 mV and measured by whole-cell voltage-camp assay
Inhibition of Cav3.3 (unknown origin) at holding potential (Vh) -100 mV and measured by whole-cell voltage-camp assay
SummaryCompounds, ActiveRelated BioAssays by Target
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