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GFP-NFAT translocation assay from US Patent US11905244: "Chemical modulators of store-operated calcium channels and their therapeutic applications"
Assay data:27 Active, 2 Activity ≤ 1 nM, 120 Activity ≤ 1 µM, 120 Tested
SummaryRelated BioAssays by Target
In-Vitro CRAC Channel Inhibition Assay in Jurkat Cells from US Patent US10668051: "Modulators of calcium release-activated calcium channel"
Assay data:56 Active, 56 Activity ≤ 1 µM, 56 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US8993612: "Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of Orai1 in human Jurkat cells assessed as CaCl2-induced increase in calcium level at 30 uM incubated for 30 mins by Fluo-4 dye based fluorescence microscopy
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Orai2/STIM1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Orai1/STIM1 (unknown origin)
Inhibition of human STIM1/Orai3 expressed in HEK293 cells assessed as reduction in Orai3 current by electrophysiological method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human STIM1/Orai1 expressed in HEK293 cells assessed as reduction in Orai1 current by electrophysiological method
Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 300 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control
Assay data:1 Tested
Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 100 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control
Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual patch clamp based electrophysiological method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 2 uM by whole cell patch clamp electrophysiological method
Inhibition of STIM/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in thapsigargin-induced Ca2+ influx at 10 uM in presence of Ca2+ by whole cell patch clamp method
Assay data:2 Active, 2 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in slope of calcium entry at 10 uM relative to control
Assay data:9 Active, 9 Tested
Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in AUC of calcium entry at 10 uM relative to control
Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in peak amplitude of calcium entry at 10 uM relative to control
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in peak amplitude of calcium entry at 10 uM relative to control
Assay data:10 Active, 10 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in calcium entry AUC at 10 uM relative to control
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response at 10 uM relative to control
Assay data:42 Tested
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