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Antagonist activity at CCR5 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at CCR2 (unknown origin)
Antagonist at CCR5 (unknown origin) assessed as inhibitory constant
Antagonist activity at human CCR5 receptor
Assay data:1 Active, 1 Tested
Inhibition of wild type CCR5 (unknown origin)
Inhibition of human CCR5
Assay data:5 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of human CCR5 in PBMC cell
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of wild type CCR2 mutant (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 6 Tested
Binding affinity to CCR2 (unknown origin) assessed as dissociation constant
Binding affinity to CCR2 (unknown origin) assessed as inhibition constant
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Binding affinity to CCR5 (unknown origin) at 10 uM by radioligand binding assay
Assay data:1 Tested
Displacement of C-45523 from CCR5 (unknown origin) expressed in CHO cells at 50 uM incubated for 40 mins by competitive binding assay based spectrophotometric method
Assay data:2 Tested
Antagonist activity at CCR5 (unknown origin) expressed in human HOS cells co-expressing HIV-1 FITC-gp120 CM235 assessed inhibition of CD4 dependent gp120 CM235 binding to CCR5 by western blot analysis
Antagonist activity at CCR5 (unknown origin) expressed in human HOS cells co-expressing HIV-1 FITC-gp120 Bal assessed inhibition of CD4 dependent gp120 Bal binding to CCR5 by western blot analysis
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
Assay data:20 Active, 19 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CCR2 (unknown origin) at 10 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human CCR5 at 10 uM relative to control
Antagonist activity at CCR2b in human Tango CCR2-bla U2OS cells using FRET B/G as substrate assessed as inhibition of CCL2- induced beta-arrestin recruitment at 1 uM incubated for 30 mins followed by CCL2 addition and measured after 16 hrs by fluorescence based analysis relative to control
Assay data:4 Tested
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