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Inhibition of ATX (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of autotaxin (unknown origin)
Inhibition of human recombinant ATX
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysis
Assay data:4 Active, 5 Activity ≤ 1 µM, 5 Tested
ATX Enzyme Activity Inhibition Assay from US Patent US20230295159: "ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:28 Active, 28 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ENPP2 Assay from US Patent US11591313: "Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof"
Assay data:10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Activity on Human ENPP2 from US Patent US11548883: "Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same"
Assay data:80 Active, 80 Activity ≤ 1 µM, 80 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of LPA-mediated ATX activation in human MDA-MB-231 cells assessed as reduction in cell migration incubated for 4 hrs in using18:1 LPC as substrate by Diff-Quick II staining based method
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as ERK phosphorylation level incubated for 30 mins by Western blot analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as AKT phosphorylation level incubated for 30 mins by Western blot analysis
Inhibition of ATX stimulated LPA1 internalization in human HeLa-Flp-In cells expressing LPA1-HA assessed as decrease in LPA1 intracellular vesicles under serum starvation condition incubated for 15 mins in presence of 18:1 LPC by confocal imaging analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LPA-mediated activation of rat ATX
Inhibition of rat ATX by Michaelis-Menten analysis
Inhibition of rat ATX lysoPLD activity assessed as residual activity using 20:0 LPC as substrate measured after 60 mins by HVA fluorescence based analysis relative to control
Inhibition of rat ATX lysoPLD activity assessed as residual activity using 18:1 LPC as substrate measured after 60 mins by HVA fluorescence based analysis relative to control
Inhibition of rat ATX lysoPLD activity assessed as residual activity using 16:0 LPC as substrate measured after 60 mins by HVA fluorescence based analysis relative to control
Inhibition of rat ATX lysoPLD activity assessed as residual activity using 14:0 LPC as substrate measured after 60 mins by HVA fluorescence based analysis relative to control
Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 20:0 LPC as substrate measured after 60 mins by HVA fluorescence based analysis
Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 18:1 LPC as substrate measured after 60 mins by HVA fluorescence based analysis
Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 16:0 LPC as substrate measured after 60 mins by HVA fluorescence based analysis
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