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Inhibition of KDM6A (unknown origin ) by TR-FRET assay
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of KDM6A (unknown origin) expressed in Escherichia coli using Biotin-H3(14-34)K27me3 peptide and measured after 1 hrs by alpha screen assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Affinity Biochemical interaction (Mass spectrometry assay) EUB0000265b KDM6A/UTX
Assay data:1 Tested
Affinity Biochemical interaction (AlphaLISA based assay) EUB0000217b KDM6A/UTX
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Inhibition of TNF release (in LPS stimulated human macrophages derived from PBMC)) EUB0000265b KDM6A/UTX
Affinity Phenotypic Cellular interaction (Inhibition of TNF release (in LPS stimulated human macrophages derived from PBMC)) EUB0000217b KDM6A/UTX
Inhibition of KDM6A (unknown origin)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
AlphaScreen Assay from Article 10.1074/jbc.M114.555052: "Human UTY(KDM6C) is a male-specific N -methyl lysyl demethylase."
KDM TR-FRET Assay from Article 10.1038/nchembio.2085: "An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells."
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of KDM6A (unknown origin) by AlphaLISA assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of UTX (unknown origin) using histone H3 peptide as substrate incubated for 30 mins followed by substrate addition by AlphaScreen assay
Inhibition of recombinant human N-terminal FLAG-tagged KDM6A expressed in baculovirus infected Sf9 insect cells using H3K27me3 peptide as substrate after 30 to 45 mins by TR-FRET assay
Assay data:2 Tested
Inhibition of KDM6A (880 to 1401 residues) (unknown origin) using H3 ( 21 to 44 residues) K27me3 as substrate preincubated for 15 min followed by substrate addition measured after 15 mins by FDH-coupled demethylase assay
Assay data:3 Tested
Human lysine demethylase 6A (1.14.11.- Histone demethylases)
Assay data:2 Active, 2 Tested
Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by AlphaLisa assay
Assay data:2 Active, 3 Activity ≤ 1 µM, 8 Tested
Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assay
Assay data:6 Tested
Inhibition of human recombinant KDM6A after 1 hr
Assay data:9 Tested
Inhibition of KDM6A
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