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Binding affinity to human partial length BRDT bromodomain 2 (K250 to E382 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:3 Active, 4 Tested
SummaryRelated BioAssays by Target
Binding affinity to BRDT bromodomain 1/2 (unknown origin) by BROMOscan assay
Binding affinity to human partial length BRDT bromodomain 1 (N21 to E137 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of human recombinant BRDT
Assay data:2 Active, 6 Tested
Inhibition of BRDT (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hr
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Binding affinity to human N-terminal His6-tagged BRDTexpressed in Escherichia coli BL21 (DE3) cells (21 to 137 residues) incubated for 1 hr
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human BRDT
Alpha Screen Assay from US Patent US11643396: "BRD4-kinase inhibitors as cancer therapeutics"
Assay data:133 Active, 98 Activity ≤ 1 µM, 156 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Effect of Compounds on BRD from US Patent US11572371: "BRD4 inhibitor"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (Isothermal titration calorimetry (ITC)) EUB0000330a BRDT
Affinity Phenotypic Cellular interaction (Cell Proliferation (Cell TiterGlo assay Promega in NMC 11060 cells)) EUB0000330a BRDT
Binding affinity to His6-fused BRDT BD2 (unknown origin) assessed as dissociation constant in PBS incubated for 1 hrs by biolayer interferometry analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to His6-fused BRDT BD1 (unknown origin) assessed as dissociation constant in PBS incubated for 1 hrs by biolayer interferometry analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to His6-fused BRDT BD2 (unknown origin) assessed as change in melting temperature at 100 uM incubated for 30 mins by thermal shift assay
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to His6-fused BRDT BD1 (unknown origin) assessed as change in melting temperature at 100 uM incubated for 30 mins by thermal shift assay
Inhibition of His-tagged recombinant BRDT (unknown origin) (21 to 153 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to BRDT BD2 (unknown origin) assessed as dissociation constant
Binding affinity to BRDT BD1 (unknown origin) assessed as dissociation constant
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