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In Vitro Assay-SREBP-2 from US Patent US20230340011: "STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS"
Assay data:513 Active, 498 Activity ≤ 1 µM, 525 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Activation of SREBP2 in mouse Neuro2a cells assessed as increase in phosphorylated ERBB4 protein expression by immunoblot analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of SREBP2 in mouse Neuro2a cells assessed as increase in ERBB4 protein expression by immunoblot analysis
Activation of SREBP2 in mouse Neuro2a cells assessed as increase in mTOR protein expression by immunoblot analysis
Activation of SREBP2 pathway in mouse primary hepatocytes assessed as increase in HMGCR mRNA expression at 0.01 to 1 uM afer 16 hrs by quantitative real-time PCR analysis
Assay data:4 Active, 4 Tested
Activation of SREBP2 pathway in mouse primary hepatocytes assessed as increase in HMGCR mRNA expression at 0.3 to 1 uM afer 16 hrs by quantitative real-time PCR analysis
Assay data:1 Active, 1 Tested
Activation of SREBP2 pathway in mouse primary hepatocytes assessed as increase in LDLR mRNA expression at 0.3 to 1 uM afer 16 hrs by quantitative real-time PCR analysis
Activation of SREBP2 pathway in mouse primary hepatocytes assessed as increase in LDLR mRNA expression at 0.01 to 1 uM afer 16 hrs by quantitative real-time PCR analysis
Inhibition of SREBP2 maturation in human HepG2 cells at 25 to 50 uM after overnight incubation by immunoblot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SREBP2 maturation in human HepG2 cells at 50 uM after overnight incubation by immunoblot analysis
Assay data:2 Tested
Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion after 16 hrs by ELISA
Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion at 10 uM after 16 hrs by ELISA
Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion at 50 uM after 16 hrs by ELISA
Inhibition of SREBP2 in human HepG2 cells assessed as downregulation of PCSK9 mRNA expression by RT-PCR analysis
Inhibition of SREBP2 maturation in human HepG2 cells at 25 uM after overnight incubation by immunoblot analysis in the presence of atorvastatin
Induction of SREBP2 maturation in human HepG2 cells at 10 uM after overnight incubation by immunoblot analysis
Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of GAPDH gene by quantitative RT-PCR analysis
Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of B2M gene by quantitative RT-PCR analysis
Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of RPL13A gene by quantitative RT-PCR analysis
Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of LDLR gene by quantitative RT-PCR analysis
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