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Inhibition of PLCgamma2 phosphorylation in RANKL-induced ICR mouse bone marrow macrophages at 10 uM preincubated for 1 hr followed by RANKL-stimulation and measured after 5 to 30 mins by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PLCgamma2 in ICR mouse bone marrow macrophages assessed as reduction in calcium influx at 10 uM after 3 days by Fluo-3/AM staining based confocal microscopic analysis
Human PLCgamma2 (Phosphoinositide-specific phospholipase C)
Inhibition of RANKL-mediated PLCgamma2 phosphorylation in mouse BMMC at 100 uM after 1 hr by Western blot analysis
Inhibition of PLCgamma2 phosphorylation in DNP-BSA-stimulated rat RBL2H3 cells by Western blotting
Assay data:1 Active, 5 Tested
Inhibition of phospholipase C gamma2 in human A431 cells assessed as reduction of calcium release at 25 uM after 45 mins by FLIPR assay
Assay data:4 Active, 4 Tested
Inhibition of phospholipase C gamma2 in human A431 cells assessed as reduction of calcium release at 50 uM after 45 mins by FLIPR assay
Assay data:5 Active, 5 Tested
Inhibition of phospholipase C gamma2 in human A431 cells assessed as reduction of calcium release after 45 mins by FLIPR assay
Assay data:1 Active, 28 Tested
Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells at 50 uM using [3H]PIP2 by flashplate biochemical assay
Assay data:26 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemical assay
Assay data:10 Active, 3 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC); N/A= not active, with <20% inhibition at 100 uM
Assay data:1 Tested
In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)
Assay data:2 Active, 3 Tested
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