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Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis
Assay data:10 Active, 7 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human FPPS pre-incubated for 30 mins using GPP and IPP by continuous spectrophotometric assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human FPPS
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Assay data:14 Tested
SummaryPubMed Citation
Summary
Cytotoxicity against mouse J774 cells assessed as reduction in cell viability
Assay data:3 Active, 6 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of human recombinant MMP-2 pretreated for 30 mins measured 2 to 4 hrs after Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition by fluorescence analysis
Assay data:9 Active, 5 Activity ≤ 1 µM, 16 Tested
Inhibition of human recombinant carbonic anhydrase 14 pretreated for 15 mins by stopped flow CO2 hydrase assay
Assay data:15 Active, 10 Activity ≤ 1 µM, 16 Tested
Inhibition of human recombinant carbonic anhydrase 12 pretreated for 15 mins by stopped flow CO2 hydrase assay
Assay data:16 Active, 16 Activity ≤ 1 µM, 16 Tested
Inhibition of human recombinant carbonic anhydrase 9 pretreated for 15 mins by stopped flow CO2 hydrase assay
Assay data:14 Active, 11 Activity ≤ 1 µM, 17 Tested
Inhibition of human recombinant carbonic anhydrase 2 pretreated for 15 mins by stopped flow CO2 hydrase assay
Assay data:10 Active, 5 Activity ≤ 1 µM, 17 Tested
Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration method
Assay data:13 Active, 6 Activity ≤ 1 µM, 22 Tested
Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method
Assay data:13 Active, 11 Activity ≤ 1 µM, 22 Tested
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method
Assay data:8 Active, 1 Activity ≤ 1 µM, 22 Tested
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method
Assay data:7 Active, 2 Activity ≤ 1 µM, 22 Tested
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
Assay data:1 Active, 3 Tested
Inhibition of APMA-activated recombinant human MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay
Assay data:8 Active, 24 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MMP8 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay
Assay data:1 Active, 24 Tested
Inhibition of MMP14 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay
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