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Binding affinity to beta-catenin/E-cadherin (unknown origin) assessed as inhibition constant
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human E-cadherin in human MKN-7 cell membrane protein fraction measured after 2 hrs by Western blotting based pull-down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
AlphaScreen Assay from US Patent US9284299: "Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions"
Assay data:3 Active, 9 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Polarization (FP) Assay from US Patent US9284299: "Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions"
Assay data:4 Active, 25 Tested
Inhibition of beta-catenin interaction with E-cadherin in human HCT-116 cells at up to 40 uM measured after 24 hrs by co-immunoprecipitation assay
Assay data:1 Tested
Inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay
Disruption of full length beta-catenin/E-cadherin interaction in human HCT116 cells incubated for 24 hrs by co-immunoprecipitation assay
Inhibition of C-terminal 6x-histidine tagged beta-catenin (138 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 DE3/N-terminally biotinylated human E-cadherin (824 to 877 residues) protein-protein interactions by Alpha-screen assay
Assay data:10 Tested
SummaryRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Competitive inhibition of wild type beta-catenin (unknown origin) expressed in Escherichia coli BL21 DE3 interaction with N-terminally biotinylated human E-cadherin (824 to 887 residues) by alpha screen assay
Inhibition of E-cadherin-Fc chimeric protein binding to E-cadherin in human OAW42 cells at 2 mM preincubated for 1 hr followed by E-cadherin-Fc addition measured after 2 hrs by ELISA relative to control
Binding affinity to E-cadherin in human OAW42 cells assessed as effect on PI3K/Akt signalling activation by measuring phosphorylation of Akt at Ser-473 residue at 1 to 2 mM by immunoblot analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
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