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PROTAC activity at VHL/SOS1 in human NCI-H460 cells harboring KRAS Q61H mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
PROTAC activity at VHL/SOS1 in human Lovo cells harboring KRAS G13D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human HCT-116 cells harboring KRAS G13D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human A549 cells harboring KRAS G12S mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human CAL-62 cells harboring KRAS G12R mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human NCI-H441 cells harboring KRAS G12V mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human SW620 cells harboring KRAS G12V mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human SK-CO-1 cells harboring G12V mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human SW480 cells harboring KRAS G12V mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human SNU1 cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human SK-LU-1 cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human PANC-1 cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human HPAF-II cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human ASPC1 cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human SNU-C2B cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human UMUC3 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human Calu-1 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human MIA PaCa-2 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation by measuring maximal efficacy at 1 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control
PROTAC activity at VHL/SOS1 in human NCI-H460 cells harboring KRAS Q61H mutant assessed as induction of SOS1 degradation incubated for 24 hrs by Immunoblot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
PROTAC activity at VHL/SOS1 in human Lovo cells harboring KRAS G13D mutant assessed as induction of SOS1 degradation incubated for 24 hrs by Immunoblot analysis
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