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ITC from Article 10.1021/cb500956g: "Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1."
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
AlphaScreen Assay from Article 10.1021/cb500956g: "Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1."
Assay data:25 Tested
Binding affinity to recombinant human N-terminal His6-tagged 53BP1 TTD (1484 to1603 residues) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human N-terminal His6-tagged lysine dye- labeled 53BP1 TTD (1484 to1603 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 10 mins by MST assay
Inhibition of recombinant human N-terminal His6-tagged 53BP1 TTD (1484 to1603 residues) expressed in Escherichia coli BL21 (DE3) cells using Biotin-H4K2Ome2 as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by AlphaScreen assay
Assay data:2 Active, 9 Tested
Binding affinity to 53BP1 (unknown origin) assessed as induction of thermal shifts at 200 uM measured for 25 mins by SYPRO orange dye thermal shift assay
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Competitive displacement of p53K382me2 from His-tagged 53BP1 tandem Tudor domain (unknown origin)
Binding affinity to 53BP1 methyllysine binding domain (unknown origin) by ITC method
Inhibition of 53BP1 methyllysine binding domain (unknown origin) after 30 mins by AlphaScreen assay
Assay data:3 Tested
Binding affinity to 6His-tagged and human 53BP1 tandem TUDOR domain (1488 to 1611 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC method
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SW620)
Assay data:15 Active, 794 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC5)
Assay data:11 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HCT15)
Assay data:18 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (CAR1)
Assay data:9 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT55)
Assay data:20 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (RCM1)
Assay data:13 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT29)
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC1)
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (LS513)
Assay data:16 Active, 794 Tested
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