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Inhibition of Top1 (unknown origin) assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 12.5 uM incubated for 25 mins by ethidium bromide staining based agarose gel electrophoresis analysis relative to control
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Top1 (unknown origin) assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 50 uM incubated for 25 mins by ethidium bromide staining based agarose gel electrophoresis analysis relative to control
Poison activity at human topoisomerase I assessed as stabilization of enzyme-DNA cleavage complex by measuring nicked DNA formation at 100 uM after 60 mins by agarose gel electrophoresis method
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of DNA topoisomerase I (unknown origin) relaxation activity at 50 uM incubated for 30 mins by chemiDoc system
Assay data:2 Tested
Inhibition of DNA topoisomerase I (unknown origin) relaxation activity at 100 uM incubated for 30 mins by chemiDoc system
Assay data:7 Active, 7 Tested
Inhibition of human DNA topoisomerase 1 assessed as reduction in pBR322 DNA relaxation at 50 to 100 uM measured by gel electrophoresis method
Assay data:1 Active, 1 Tested
Inhibition of DNA topoisomerase 1 (unknown origin) at 25 to 50 uM measured by agar gel electrophoresis relative to control
Assay data:2 Active, 2 Tested
Inhibition of topoisomerase 1 (unknown origin) assessed as relaxation of pBR322 plasmid DNA and incubated for 10 mins
Inhibition of pBR322 DNA binding to topoisomerase 1 (unknown origin) at 1 to 5 mM measured after 30 mins by electrophoretic mobility shift assay
Assay data:3 Tested
Inhibition of topoisomerase 1 (unknown origin) assessed as DNA intercalation at 1 to 5 mM using pBR322 DNA as substrate measured after 30 mins by gel electrophoresis relative to control
Inhibition of topoisomerase 1 (unknown origin) assessed as DNA intercalation at 1 mM using pBR322 DNA as substrate measured after 30 mins by gel electrophoresis relative to control
Poison activity at topoisomerase 1 (unknown origin) assessed as stabilization of enzyme-DNA cleavage complex by measuring increase in nicked DNA formation at 1 mM using pBR322 DNA as substrate after 30 mins by agarose gel electrophoresis
Poison activity at topoisomerase 1 (unknown origin) assessed as stabilization of enzyme-DNA cleavage complex by measuring increase in nicked DNA formation at 1 to 3 mM using pBR322 DNA as substrate after 30 mins by agarose gel electrophoresis
Inhibition of topoisomerase 1 (unknown origin) assessed as reduction in relaxation of supercoiled DNA at 1 mM using pBR322 plasmid DNA as substrate measured after 30 mins by gel electrophoresis relative to control
Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis relative to control
Assay data:6 Tested
Catalytic inhibitor of non-intercalative topoisomerase 1 (unknown origin) assessed as increase in nicked DNA level at 100 to 250 uM measured by cleavage complex assay
Catalytic inhibitor of non-intercalative topoisomerase 1 (unknown origin) assessed as binding to minor groove at 100 to 500 uM measured by cleavage complex assay
Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM by agarose gel electrophoresis relative to control
Assay data:8 Tested
Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM by agarose gel electrophoresis (Rvb = 38.4%)
Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis (Rvb = 74.7%)
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