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Selectivity interaction (Dundee panel (140 kinases and 19 lipid kinases)) EUB0000631a MAP3K7
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (Invitrogen)) EUB0000629a MAP3K7
Inhibition of human TAK1 at 50 uM using casein as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TAK1 (unknown origin) at 1 uM relative to control
Inhibition of human TAK1 at 1 uM incubated for 30 mins in presence of [gamma-33P]ATP by kinase selectivity assay
Assay data:3 Tested
TAK1 DiscoveRx kinase panel
TAK1(h) Kinase panel
Inhibition of TAK1 (unknown origin) at 1 uM
Inhibition of human recombinant TAK1 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-FLGFTYVAP as substrate incubated for 90 min by LANCE detection method
Inhibition of TAK1 (unknown origin) in presence of MBP as substrate by ADP-Glo assay
Assay data:28 Active, 25 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
TaK1-TaB1 Inhibitor Assays from US Patent US10434085: "Non-aromatic difluoro analogues of resorcylic acid lactones"
Assay data:10 Active, 6 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Assay from US Patent US9505765: "4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment"
Assay data:36 Active, 33 Activity ≤ 1 µM, 36 Tested
Kinase Assay from Article 10.1021/cb300729y: "De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments."
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Kinase Inhibition Assays from US Patent US10266537: "3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof"
Assay data:27 Active, 4 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 27 Tested
KinomeScan assay: inhibition of TAK1
Assay data:108 Tested
TAK1(M3K7CHY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
MAP3K7(M315LGP1) Takeda global kinase panel
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