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Inhibition of STAT1 in human AGS cells assessed as inhibition of STAT1 phosphorylation level at Tyr701 at 0.3 to 3 uM by western blot assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of JAK/STAT (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of STAT1 phosphorylation in human MGC-803 cells assessed as effect on total protein at 1 to 3 uM incubated for 24 hrs by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of STAT1 phosphorylation in human AGS cells assessed as effect on total protein at 1 to 3 uM incubated for 24 hrs by Western blot analysis
Binding affinity to His-tagged human STAT1 (132 to 713 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to STAT1 (unknown origin) transfected in MKN-45 cells assessed as change in melting temperature at 5 uM by thermal shift assay
Thermal stabilization of STAT1 in human BXPC-3 cells at 10 microM at 50.6 degreeC incubated for 1 hrs by cellular thermal shift assay
Thermal stabilization of STAT1 in human BXPC-3 cells at 10 microM at 47.4 degreeC incubated for 1 hrs by cellular thermal shift assay
Thermal stabilization of STAT1 in human BXPC-3 cells at 10 microM at 44.6 degreeC incubated for 1 hrs by cellular thermal shift assay
Thermal stabilization of STAT1 in human BXPC-3 cells at 10 microM at 42.9 degreeC incubated for 1 hrs by cellular thermal shift assay
Inhibition of IFN-gamma-induced Stat1 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of STAT1 phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis
Bioassay from US Patent US11111253: "6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity"
Assay data:49 Active, 1 Activity ≤ 1 µM, 117 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Bioassay Evaluation from US Patent US10618914: "6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity"
Assay data:15 Active, 43 Tested
Electrophoretic Mobility Shift Assay (EMSA) from Article 10.1073/pnas.0609757104: "Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity."
Electrophoretic Mobility Shift Assay (EMSA) from Article 10.1021/cb7001973: "An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects."
Electrophoretic Mobility Shift Assay (EMSA) from Article 10.1016/j.bmcl.2007.01.077: "Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains."
Assay data:9 Tested
Inhibition of STAT1 phosphorylation at Y701 residue in human HCC70 cells at 0.3 to 3 uM after 3 hrs by Western blotting analysis
Inhibition of STAT1 phosphorylation at Y701 residue in human MDA-MB-231 cells at 0.3 to 3 uM after 3 hrs by Western blotting analysis
Inhibition of IFN-gamma-induced STAT1 transcriptional activity in human HepG2 cells by luciferase reporter gene assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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