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Binding affinity to recombinant human His-tagged RAD51 expressed in Escherichia coli Rosetta2(DE3)pLysS cells in presence of BRC4 by 19F-NMR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human His-tagged RAD51 expressed in Escherichia coli Rosetta2(DE3)pLysS cells by 19F-NMR assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of RAD51 in human U2OS cells at 20 to 80 uM measured by direct repeats green fluorescent protein (DR-GFP) reporter assay
Assay data:2 Active, 2 Tested
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as random coil content at 15 uM by circular dichroism spectroscopy (Rvb = 39.2%)
Assay data:9 Tested
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as beta-turn content at 15 uM by circular dichroism spectroscopy (Rvb = 16.2%)
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as beta-sheet content at 15 uM by circular dichroism spectroscopy (Rvb = 17.7%)
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as reduction in fluorescence intensity by fluorescence spectroscopy
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as binding constant by fluorescence spectroscopy
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as quenching rate constant by fluorescence spectroscopy
Binding affinity to RAD51 (158 to 180 residues) (unknown origin) assessed as alpha-helical content at 15 uM by circular dichroism spectroscopy (Rvb = 26.9%)
Stabilization of RAD51 foci in human cisplatin-resistant MCF7 cells assessed as increase in RAD51 positive cells at 20 uM pretreated with cisplatin for 8 hrs followed by compound addition and measured after 24 hrs by immunofluorescence microscopic analysis
Stabilization of RAD51 foci in human MCF7 cells assessed as increase in RAD51 positive cells at 20 uM pretreated with cisplatin for 8 hrs followed by compound addition and measured after 24 hrs by immunofluorescence microscopic analysis
Compound Primary Screening from US Patent US11291655: "RAD51 inhibitors"
Assay data:101 Active, 31 Activity ≤ 1 µM, 171 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ELISA assay from Article 10.1021/acschembio.7b00707: "Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors."
Assay data:2 Tested
Inhibition of human RAD51 using 90-mer ssDNA as substrate measured after 30 mins by D-loop assay
Binding affinity to Rad51 in human BxPC3 cells assessed as reduction in protein-mediated homologous recombination at 40 uM measured after 16 hrs by reporter gene based PCR analysis relative to control
Binding affinity to Rad51 in human BxPC3 cells assessed as reduction in protein-mediated homologous recombination at 20 uM measured after 16 hrs by reporter gene based PCR analysis relative to control
Binding affinity to Rad51 in human BxPC3 cells assessed as reduction in protein-mediated homologous recombination at 5 to 30 uM measured after 16 hrs by reporter gene based PCR analysis
Displacement of N-terminal biotinylated-BRC4 from recombinant human Rad51 expressed in Escherichia coli by ELISA
Assay data:1 Active, 42 Tested
Inhibition of RAD51 (unknown origin) assessed as inhibition of DNA pairing by measuring D-loop formation between [32P]-ssDNA and homologous supercoiled pUC19 DNA at 10 times RAD52 IC50 incubated for 15 mins by gel electrophoresis method relative to control
Assay data:17 Tested
SummaryRelated BioAssays by Target
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