BioAssay by Target (List) for Gene (Select 56848) - PubChem BioAssay - NCBI

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Select item 19566861.

new record, indexing in progress

AID:: 1956686

Select item 19239192.

new record, indexing in progress

AID:: 1923919

Select item 19239173.

new record, indexing in progress

AID:: 1923917

Select item 19239154.

new record, indexing in progress

AID:: 1923915

Select item 19239135.

new record, indexing in progress

AID:: 1923913

Select item 19239096.

new record, indexing in progress

AID:: 1923909

Select item 19239077.

new record, indexing in progress

AID:: 1923907

Select item 19239058.

new record, indexing in progress

AID:: 1923905

Select item 19239039.

new record, indexing in progress

AID:: 1923903

Select item 192347410.

new record, indexing in progress

AID:: 1923474

Select item 190878311.

Inhibition of recombinant SPHK2 (unknown origin) expressed in baculovirus infected Sf9 insect cells using D-erythro-sphingosine as substrate incubated for 20 mins in presence of gamma-[32P]ATP by liquid scintillation counting method

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:1 Tested

AID:: 1908783

Summary PubMed Citation Related BioAssays by Target

Select item 190878112.

Inhibition of human SPHK2 by biochemical assay

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:1 Active, 1 Tested

AID:: 1908781

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 190877913.

Inhibition of SPHK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:2 Tested

AID:: 1908779

Summary PubMed Citation Related BioAssays by Target

Select item 190868914.

Inhibition of SPHK2 (unknown origin) using sphingosine-fluorescein as substrate incubated for 1 hr in presence of ATP by mobility shift assay

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:12 Tested

AID:: 1908689

Summary PubMed Citation Related BioAssays by Target

Select item 189383515.

Binding affinity to Sphk2 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:1 Active, 1 Tested

AID:: 1893835

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187626516.

Binding affinity to recombinant SphK2 (unknown origin) ADP Quest assay system

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:1 Active, 1 Tested

AID:: 1876265

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187622817.

Binding affinity to Sphk2 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:1 Active, 1 Tested

AID:: 1876228

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 179498018.

Broken Cell Assay from US Patent US9688668: "Long chain base sphingosine kinase inhibitors"

Source:: BindingDB

Protein Targets:: Sphingosine kinase 1; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1794980

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179497919.

Scintillation Proximity Assay from US Patent US9688668: "Long chain base sphingosine kinase inhibitors"

Source:: BindingDB

Protein Targets:: Sphingosine kinase 1; ...
Total:: 2

Assay data:19 Active, 19 Activity ≤ 1 µM, 71 Tested

AID:: 1794979

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179118520.

SPHK2 Kinase screen

Source:: ChEMBL

Protein Target:: Sphingosine kinase 2

Assay data:1 Tested

AID:: 1791185

Summary Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (81)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (23)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (79)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (164)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (159)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (47)
BioAssays deposited by other experimentalists

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