BioAssay by Target (List) for Gene (Select 5594) - PubChem BioAssay - NCBI

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Select item 19200991.

p38 Inhibitory Potency Assay from US Patent US11844801: "Oral compositions of MK2 pathway inhibitor for treatment of immune conditions"

Source:: BindingDB

Protein Targets:: MAP kinase-activated protein kinase 5; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1920099

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19195902.

ERK2 Enzymatic Assay from US Patent US11708364: "Azaindole derivatives and their use as ERK kinase inhibitors"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase 1; ...
Total:: 1

Assay data:90 Active, 92 Activity ≤ 1 µM, 92 Tested

AID:: 1919590

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19195213.

Biochemical Assay (10 uM) from US Patent US11685719: "Pyridinone MK2 inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase 1; ...
Total:: 2

Assay data:23 Active, 5 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested

AID:: 1919521

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19195204.

Biochemical Assay (1 uM) from US Patent US11685719: "Pyridinone MK2 inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: MAP kinase-activated protein kinase 5; ...
Total:: 3

Assay data:23 Active, 2 Activity ≤ 1 µM, 24 Tested

AID:: 1919520

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19141735.

Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1914173

Summary Related BioAssays by Target

Select item 19134066.

Selectivity interaction (Enzymatic assay) EUB0000609a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Tested

AID:: 1913406

Summary Compounds, Active Related BioAssays by Target

Select item 19134057.

Selectivity interaction (Ambit kinase binding assay panel) EUB0000609a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1913405

Summary Related BioAssays by Target

Select item 19132168.

Affinity Biochemical interaction (KdELECT (DiscoverX)) EUB0000298b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913216

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131629.

Affinity Biochemical interaction (Enzymatic assay) EUB0000700a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Tested

AID:: 1913162

Summary Compounds, Active Related BioAssays by Target

Select item 191295810.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000298b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912958

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191290411.

Affinity On-target Cellular interaction (Cellular assay (inhibition of RSK phosphorylation, A375SM cells)) EUB0000700a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1912904

Summary Related BioAssays by Target

Select item 191277312.

Affinity Phenotypic Cellular interaction (Anti-proliferation assay (A375SM cells)) EUB0000298b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912773

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191274613.

Affinity Phenotypic Cellular interaction (Anti-proliferation assay (A375SM cells)) EUB0000700a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1912746

Summary Related BioAssays by Target

Select item 191256014.

Thermal Shift Assay. Domain: start/stop: M1-S360

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:27 Tested

AID:: 1912560

Summary Related BioAssays by Target

Select item 191255915.

Thermal Shift Assay. Domain: start/stop: M1-S360

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1912559

Summary Related BioAssays by Target

Select item 191057216.

Inhibition of MAPK1 (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:2 Tested

AID:: 1910572

Summary PubMed Citation Related BioAssays by Target

Select item 190952217.

Inhibition of ERK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1909522

Summary PubMed Citation Related BioAssays by Target

Select item 190657918.

Inhibition of ERK1/2 phosphorylation in human HL-60 cells at 10 uM measured after 2 hrs by Immunoblotting analysis

Source:: ChEMBL

Protein Targets:: Mitogen-activated protein kinase 1; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 1906579

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 190240019.

Inhibition of MAPK1 (unknown origin) at 50 nM by Z'LYTE screening method relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:12 Tested

AID:: 1902400

Summary PubMed Citation Related BioAssays by Target

Select item 189994720.

Inhibition of human MAPK1 at 10 uM by radiometric kinase activity assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1899947

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (16)
BioAssays with protein sequences specified as targets
RNAi Target, Active (10)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (355)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (57)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (188)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (354)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (41)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (2,069)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (52)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (20)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (1,045)
BioAssays extracted from the literature
NIH MLP (15)
BioAssays deposited by the NIH Molecular Libraries Program
Other (1,060)
BioAssays deposited by other experimentalists

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