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Inhibition of recombinant AMPK A2/B1/G1 (unknown origin) at 0.1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant AMPK A1/B1/G1 (unknown origin) at 0.1 uM relative to control
Inhibition of recombinant AMPK (A2/B1/G3) (unknown origin) at 0.1 uM relative to control
Activation of AMPK (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of AMPK in human HepG2 cells assessed as reduction in mitochondrial ATP production incubated for 1 hr
Assay data:24 Active, 1 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 25 Tested
Activation of AMPK in human HepG2 cells assessed as increase in ACC phosphorylation at Ser79 incubated for 1 hr
Assay data:54 Active, 3 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 55 Tested
Activation of AMPK pathway in human HCCLM3 cells assessed as increase in AMPK phosphorylation level at 5 nM measured after 1 hr by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In Vitro pAMPK1 Kinase Activation Assay from US Patent US11407768: "AMPK activators"
Assay data:51 Active, 29 Activity ≤ 1 nM, 51 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro AMPK Activation Assay from US Patent US9527839: "Benzimidazole tetrahydropyran derivatives"
Assay data:25 Active, 25 Activity ≤ 1 µM, 25 Tested
Activation Assay from US Patent US9422312: "Azabenzimidazole derivatives"
Assay data:21 Active, 20 Activity ≤ 1 µM, 21 Tested
33P-Based Assay from US Patent US9394285: "Indole and indazole compounds that activate AMPK"
Assay data:176 Active, 1 Activity ≤ 1 nM, 172 Activity ≤ 1 µM, 177 Tested
In Vitro AMPK Activation Assay from US Patent US9290517: "Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives"
Assay data:25 Active, 3 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Kinase Assay from US Patent US9040694: "Compounds and methods useful for directing stem cell differentiation"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
in vitro Kinase Assay from Article 10.1021/cb9002865: "In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors."
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
in vitro AMPK activation assays from US Patent US10053471: "Azabenzimidazole derivatives"
Assay data:17 Active, 15 Activity ≤ 1 µM, 17 Tested
AMPK A1/B1/G1 Kinase activity screen
SummaryRelated BioAssays by Target
AMPK A2/B1/G1 Kinase screen
AMPK A1/B1/G1 Kinase screen
AMPK A1B1G1 Invitrogen selectivity data (BI)
SummaryCompounds, ActiveRelated BioAssays by Target
AMPK A2B1G1 Invitrogen selectivity data (BI)
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