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Furin Enzyme Assay from US Patent US11773078: "Furin inhibitors"
Assay data:396 Active, 188 Activity ≤ 1 nM, 396 Activity ≤ 1 µM, 396 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant human furin assessed as remaining activity at 50 uM using pERTKR-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorometric assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human furin using Pyr-RTKR-AMC as substrate preincubated for 30 mins followed by substrate addition and measured by fluorescence based assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of furin in human U2OS cells measured after 24 hrs by fluorescence assay
Assay data:18 Tested
Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrs
Assay data:18 Active, 10 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of soluble recombinant human furin using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate and measured by fluorescence assay
Assay data:7 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of soluble human furin using boc-RVRR-MCA as substrate incubated for 45 mins and measured by fluorescence assay
Inhibition of furin (unknown origin) using Pyr-RTKR-MCA as substrate incubated for 30 mins and measured by FRET assay
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
Inhibition of furin (unknown origin) expressed in chinese hamster CHO cells expressing GRAP-furin assessed as SEAP activity at 100 uM and measured by fluorescence based assay relative to control
Assay data:10 Tested
Inhibition of Recombinant vaccinia-expressed furin (unknown origin) using Pyr-RTKR-MCA as substrate and measured by fluorescence based assay
Assay data:14 Active, 9 Activity ≤ 1 µM, 14 Tested
Inhibition of recombinant human furin using Phac-Arg-Val-Arg-Arg-AMC as substrate incubated for 30 mins and measured by microplate reader method
Assay data:8 Active, 6 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of recombinant human furin protease
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of furin (unknown origin)
Assay data:25 Active, 11 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 26 Tested
Inhibition of human furin expressed in HEK293 cells using pGlu-Arg-Thr-LysArg-AMC as substrate and measured by fluorescence based assay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
TMPRSS2 pericellular activity screening assay from Article 10.1038/s41586-022-04661-w: "A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic."
Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Assay from US Patent US9266828: "Inhibitors of Furin and other pro-protein convertases"
Inhibition of recombinant human furin Protease
Potency index, ratio of CF1 Ki to test compound Ki for recombinant soluble human furin using pyroGlu-Arg-Thr-Lys-Arg-methyl-coumaryl-7-amide as substrate measured after 1 hr
Assay data:3 Tested
Inhibition of recombinant soluble human furin using pyroGlu-Arg-Thr-Lys-Arg-methyl-coumaryl-7-amide as substrate measured after 1 hr
Assay data:97 Active, 95 Activity ≤ 1 µM, 97 Tested
Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
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