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ADP-Glo Assay from US Patent US11555012: "ACLY inhibitors and uses thereof"
Assay data:196 Active, 109 Activity ≤ 1 µM, 474 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ADP-Glo Assay from US Patent US11492341: "ACLY inhibitors and uses thereof"
Assay data:6 Active, 6 Activity ≤ 1 µM, 150 Tested
Inhibition of ACL (unknown origin)
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to ACYL in human PC9 cells incubated for 1 hr by ABPP-SILAC assay
Assay data:1 Active, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to ACLY in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay
Competitive inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assay
Assay data:2 Active, 2 Tested
Inhibition of ATP citrate lyase in snail expressing HMLE cells assessed as suppression of cancer stemness by measuring CD44 positive/CD24 negative cells at 25 uM after 48 hrs by flow cytometry (Rvb = 88.6 %)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ATP citrate lyase in snail expressing HMLE cells assessed as suppression of cancer stemness by measuring CD44 positive/negative and CD24 positive cells at 25 uM after 48 hrs by flow cytometry (Rvb = 4.85 %)
Inhibition of ATP citrate lyase in snail expressing HMLE cells assessed as suppression of cancer stemness by measuring CD44 positive/CD24 negative cells at 10 uM after 48 hrs by flow cytometry (Rvb = 88.6 %)
Inhibition of ATP citrate lyase in snail expressing HMLE cells assessed as suppression of cancer stemness by measuring CD44 positive/negative and CD24 positive cells at 10 uM after 48 hrs by flow cytometry (Rvb = 4.85 %)
Inhibition of ATP citrate lyase in snail expressing HMLE cells assessed as suppression of cancer stemness by measuring increase in CD44 positive/negative and CD24 positive cells after 48 hrs by flow cytometry
Inhibition of ATP citrate lyase in snail expressing HMLE cells assessed as suppression of cancer stemness by measuring decrease in CD44 positive/CD24 negative cells after 48 hrs by flow cytometry
Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ATP citrate lyase (unknown origin) at 100 uM using sodium citrate as substrate in presence of CoA/ATP by ADP-Glo luminescence assay relative to control
Assay data:24 Tested
Inhibition of ATP citrate lyase (unknown origin) at 10 uM using sodium citrate as substrate in presence of CoA/ATP by ADP-Glo luminescence assay relative to control
Inhibition of ATP citrate lyase (unknown origin) at 3.3 uM using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assay relative to control
Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 14 Tested
Inhibition of ATP citrate lyase (unknown origin) at 10 uM using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assay relative to control
Assay data:11 Tested
Inhibition of ACLY in human HepG2 cells assessed as reduction in fatty acid synthesis at 30 uM relative to control
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