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Selectivity interaction (Kinase panel (ProQinase, FlashPlate?-based radiometric assay, 10 M ATP)) EUB0000006b MAP3K11
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human MLK3 in presence of ATP by radiometric assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human MLK3 at 1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
MLK3 DiscoveRx kinase panel
MLK3(h) Kinase panel
Inhibition of MLK3 (unknown origin) at 1 uM
In Vitro Kinase Assay from US Patent US10787436: "Inhibitors of cyclin-dependent kinase 7 (CDK7)"
Assay data:38 Active, 37 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Radiometric Filter Plate MLK3 Assay from US Patent US10485800: "Mixed lineage kinase inhibitors for HIV/AIDS therapies"
Assay data:145 Active, 202 Activity ≤ 1 µM, 202 Tested
Mixed-Lineage Kinase Assay from Article 10.1021/jm8005838: "Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models."
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Radiometric Filter Plate Assay from US Patent US9814704: "Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors"
Assay data:111 Active, 166 Activity ≤ 1 µM, 166 Tested
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."
Assay data:16 Active, 16 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
KinomeScan assay: inhibition of MLK3
Assay data:108 Tested
MLK3(M311LGF1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
MAP3K11 ProQinase selectivity panel
MAP3K11 (MLK3) Kinase screen
MAP3K11 Invitrogen selectivity data (BI)
MLK3(h) Eurofins Kinase panel
MLK3(h) Millipore kinase panel
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