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Inhibition of A-Raf (unknown origin) at 1 uM relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of A-Raf (unknown origin) at 1 uM in presence of ATP by hotspot kinase assay
Assay data:3 Tested
A-Raf(h) Kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ARAF (unknown origin) at 1 uM
Inhibition of human recombinant A-Raf assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
Inhibition of recombinant human A-Raf (273 to end residues) assessed as residual activity at 0.5 uM using myelin as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting method relative to control
KiNativ assay from US Patent US9187474: "Raf inhibitor compounds"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
A-Raf(h) Eurofins kinase panel
A-Raf(h) Eurofins Kinase panel
A_Raf(h) Millipore kinase panel
Inhibition of A-RAF (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human ARAF using MEK1 as substrate assessed as enzyme activity incubated for 2 hrs by [gamma-33P]-ATP assay relative to control
Inhibition of recombinant human A-Raf (273 to end residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ARAF in human NCI-H929 cells at 10 uM by mass spectroscopic analysis relative to control
Inhibition of ARAF in human NCI-H929 cells by mass spectroscopic analysis
Assay data:2 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of recombinant human A-Raf (273 to end residues) assessed as residual activity at 10 uM using myelin basic protein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay relative to control
Inhibition of A-Raf (unknown origin) in presence of [gamma33]-ATP at 10 uM by liquid scintillation counting analysis relative to control
Inhibition of ARAF (unknown origin) assessed as residual activity assessed as residual activity at 1 uM relative to control
Inhibition of human ARAF assessed as residual activity using MEK1 as substrate at 1 uM by [gamma-33P]-ATP assay relative to control
Inhibition of human ARAF using MEK1 as substrate assessed as residual activity at 1 uM by [gamma-33P]-ATP assay relative to control
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