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Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells at 300 uM incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay
Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells at >= 100 uM incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells assessed as GABA-induced maximum response incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay relative to GABA
Assay data:12 Tested
Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay
Assay data:10 Active, 1 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human GABAA receptor rho1 subunit (GABAA receptors)
Assay data:13 Active, 13 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay relative to GABA
Assay data:5 Tested
Agonist activity at human GABAA rho1 expressed in tsA-201cells at 1 mM by FLIPR membrane potential blue assay
Assay data:2 Active, 2 Tested
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay
Assay data:8 Active, 2 Activity ≤ 1 µM, 20 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Displacement of [3H]EBOB from recombinant Homo sapiens (human) GABA rho1 receptor
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human GABA C receptor subunit rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current at 3 uM by two-electrode voltage clamp method
Assay data:2 Tested
Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current production at 300 uM after 2 to 5 days by two-electrode voltage-clamp electrophysiological assay relative to control
Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current production after 2 to 5 days by two-electrode voltage-clamp electrophysiological assay
Assay data:2 Active, 8 Tested
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