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Drug metabolism in rat hepatocytes assessed as UGT1A1-mediated acylglucuronide metabolite formation at 10 uM after 4 hrs by HPLC-UV and mass spectrometric analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Ratio of test compound IC50 to atazanavir IC50 for UGT1A1 in rat liver microsomes
Assay data:1 Tested
Ratio of test compound IC50 to atazanavir IC50 for recombinant rat UGT1A1
Inhibition of UGT1A1 in rat liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins by LC-MS/MS analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant rat UGT1A1 using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins by LC-MS/MS analysis
Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin diglucuronide level at 10 uM after 45 mins in presence of UDPGA by HPLC analysis
Assay data:1 Active, 1 Tested
Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin monoglucuronide level at 10 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis relative to control
Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin diglucuronide level at 10 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis relative to control
Inhibition of UGT1A in rat hepatocytes assessed as increase in unconjugated bilirubin level at 75 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis
Assay data:2 Tested
Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin diglucuronide level at 75 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis
Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin monoglucuronide level at 75 uM preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis
Inhibition of UGT1A in rat hepatocytes assessed as decrease in bilirubin monoglucuronide level at 10 uM after 45 mins in presence of UDPGA by HPLC analysis
Inhibition of UGT1A in rat hepatocytes preincubated for 2 mins followed by UDPGA addition measured after 45 mins by HPLC analysis
Assay data:4 Tested
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