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TR-FRET BRD4 Binding Assay from US Patent US11840533: "Pyridinone-based epigenetic modifiers and uses thereof"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
AlphaScreen Assay from US Patent US11702416: "1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins"
Assay data:98 Active, 98 Activity ≤ 1 µM, 98 Tested
Alpha Screen Assay from US Patent US11643396: "BRD4-kinase inhibitors as cancer therapeutics"
Assay data:133 Active, 98 Activity ≤ 1 µM, 156 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay (BRD4-2) from US Patent US11584756: "Heterocyclic compounds as BET inhibitors"
Assay data:33 Active, 1 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 33 Tested
Binding Assay (BRD4-1) from US Patent US11584756: "Heterocyclic compounds as BET inhibitors"
Assay data:23 Active, 13 Activity ≤ 1 µM, 31 Tested
Inhibitory Effect of Compounds on BRD from US Patent US11572371: "BRD4 inhibitor"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibitory Action on Binding of BRD4 Protein and Ligand Test Method 2 from US Patent US11542273: "Amide compound having bet proteolysis-inducing action and medicinal application thereof"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibitory Action on Binding of BRD4 Protein and Ligand Test Method 1 from US Patent US11542273: "Amide compound having bet proteolysis-inducing action and medicinal application thereof"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
BRD4 AlphaScreen Assay from US Patent US11498926: "Tricyclic heterocycles as BET protein inhibitors"
Assay data:275 Active, 269 Activity ≤ 1 µM, 275 Tested
Assay data:275 Active, 254 Activity ≤ 1 µM, 275 Tested
Inhibition of BRD4 BD1 (unknown origin) measured by TR-FRET assay
Assay data:39 Active, 34 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BRD4 BD2 (unknown origin) measured by TR-FRET assay
Assay data:38 Active, 26 Activity ≤ 1 µM, 45 Tested
Inhibition of BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) using [Lys(Ac)5/8/12/16]-histone H4 (1 to 21residues)-GGK as substrate incubated for 30 mins by TR-FRET assay
Assay data:24 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as thermal stabilization at 10 uM by SYPRO orange dye based DSF assay
Selectivity interaction (ITC) EUB0000323b BRD4
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Bromodomain panel (DSF assay)) EUB0000323b BRD4
Selectivity interaction (AlphaScreen) EUB0000323b BRD4
Selectivity interaction (ITC) EUB0000205c BRD4
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (Bromodomain panel (DSF assay)) EUB0000201c BRD4
Selectivity interaction (AlphaScreen assay) EUB0000192d BRD4
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