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Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in c-fos expression measured after 3 days by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in NFATc1 expression measured after 3 days by Western blot analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in NFATc1 mRNA level at 2.5 uM measured after 3 days by Trizol-reagent-based qRT-PCR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP mRNA level at 2.5 uM measured after 3 days by Trizol-reagent-based qRT-PCR analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced bone resorption at 1 to 5 uM measured after 2 days by toluidine blue staining-based confocal microscopic analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in nuclei number of F-actin ring formation at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by rhodamine phalloidin/DAPI staining-based microscopic analysis
Assay data:4 Tested
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in nuclei size of F-actin ring formation at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by rhodamine phalloidin/DAPI staining-based microscopic analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in cathepsin K mRNA level measured after 3 days by Trizol-reagent-based qRT-PCR analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in cathepsin K mRNA level at 2.5 uM measured after 3 days by Trizol-reagent-based qRT-PCR analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP activity at 5 uM measured after 3 days by colorimetric assay relative to control
Assay data:1 Active, 37 Tested
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis
Assay data:1 Active, 5 Tested
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis relative to control
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 10 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis relative to control
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP mRNA level measured after 3 days by Trizol-reagent-based qRT-PCR analysis
Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in NFATc1 mRNA level measured after 3 days by Trizol-reagent-based qRT-PCR analysis
Inhibition of RANKL/RANK protein-protein interaction in mouse RAW264.7 cells assessed as reduction in RANKL-stimulated NF-kB signaling pathway activation by measuring decrease in IkBalpha phosphorylation after 2 hrs by immunoblot assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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