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Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in cell proliferation at 40 to 80 uM incubated for 3 days and measured every 24 hrs by MTS assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in cell proliferation at 20 to 60 uM incubated for 3 days and measured every 24 hrs by MTS assay
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in Akt phosphorylation at 20 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in ERK1/2 phosphorylation at 20 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as effect on Ras-GTP levels at 20 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by GST-Raf1 effector domain pulldown assay
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in Akt phosphorylation at 20 to 40 uM pre-incubated for 16 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in ERK1/2 phosphorylation at 20 to 40 uM pre-incubated for 16 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as effect on Ras-GTP levels at 20 to 40 uM pre-incubated for 16 hrs before EGF stimulation for 5 mins by GST-Raf1 effector domain pulldown assay
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as effect on Rac1-GTP levels at 20 to 50 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by GST-Raf1 effector domain pulldown assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of SOS1 in overnight serum-starved and H-RasG12V transduced mouse MEF assessed as reduction in Akt phosphorylation at 10 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved and H-RasG12V transduced mouse MEF assessed as reduction in ERK1/2 phosphorylation at 10 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved and H-RasG12V transduced mouse MEF assessed as reduction in cell proliferation at 10 to 40 uM incubated for 3 days by MTS assay
Inhibition of SOS1 in overnight serum-starved mouse MEF assessed as reduction in Akt phosphorylation at 10 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse MEF assessed as reduction in ERK1/2 phosphorylation at 10 to 40 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse MEF assessed as reduction in cell proliferation at 10 to 40 uM incubated for 3 days by MTS assay
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in cell proliferation at 20 to 50 uM incubated for 3 days and measured every 24 hrs by MTS assay
Inhibition of SOS1 in mouse NIH/3T3 cells assessed as reduction in EGFR phosphorylation at 20 to 100 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as reduction in Akt phosphorylation at 20 to 100 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by Western blot analysis
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as effect on R-Ras-GTP levels at 20 to 50 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by GST-Raf1 effector domain pulldown assay
Inhibition of SOS1 in overnight serum-starved mouse NIH/3T3 cells assessed as effect on Ras-GTP levels at 20 to 50 uM pre-incubated for 2 hrs before EGF stimulation for 5 mins by GST-Raf1 effector domain pulldown assay
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