BioAssay by Target (List) for Gene (Select 2066) - PubChem BioAssay - NCBI

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Select item 19194551.

Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 23

Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested

AID:: 1919455

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154702.

Selectivity interaction (Enzymatic activity assay) EUB0000596aBDA ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915470

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19136803.

Selectivity interaction (Z?-LYTE assay) EUB0000638a ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913680

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19136794.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000638a ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Tested

AID:: 1913679

Summary Related BioAssays by Target

Select item 19133765.

Affinity Biochemical interaction (Competition binding assay (DiscoverX)) EUB0000596aBDA ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913376

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131016.

Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913101

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19128677.

Affinity Phenotypic Cellular interaction (Alamar Blue? assay (growth inhibition of H3255 cells expressing both EGFR and HER2)) EUB0000596aBDA ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Tested

AID:: 1912867

Summary Compounds, Active Related BioAssays by Target

Select item 19126888.

Affinity Phenotypic Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (Promega; growth inhibitory activity in Rec-1 cells)) EUB0000646a ERBB4

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912688

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19087019.

Inhibition of ERBB4 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:2 Tested

AID:: 1908701

Summary PubMed Citation Related BioAssays by Target

Select item 190448510.

Inhibition of HER4 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1904485

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189971011.

Inhibition of HER4 (unknown origin) at 0.3 uM relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Tested

AID:: 1899710

Summary PubMed Citation Related BioAssays by Target

Select item 189867712.

Inhibition of ERBB4 (unknown origin) assessed as residual activity at 1 uM by radiometric 33 PanQuinase assay relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Tested

AID:: 1898677

Summary PubMed Citation Related BioAssays by Target

Select item 189541613.

Inhibition of HER4 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Tested

AID:: 1895416

Summary PubMed Citation Related BioAssays by Target

Select item 189415914.

Inhibition of GST-tagged ERBB4 (unknown origin) expressed in insect cells by ELISA

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894159

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188548215.

Inhibition of HER4 (unknown origin) at 0.5 uM assessed as competition rate relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Tested

AID:: 1885482

Summary PubMed Citation Related BioAssays by Target

Select item 188543516.

Inhibition of HER4 (unknown origin) at 0.5 uM relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Tested

AID:: 1885435

Summary PubMed Citation Related BioAssays by Target

Select item 187810417.

Binding affinity to ERBB4 (unknown origin) assessed as dissociation constant by KINOMEscan analysis

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested

AID:: 1878104

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187593618.

Inhibition of ErbB-4 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1875936

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187176719.

Inhibition of ERBB4 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-4

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1871767

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186698920.

Inhibition of human GST-fused EGFR T790M/C797S double mutant expressed in Sf9 insect cells by HTRF assay

Source:: ChEMBL

Protein Targets:: Epidermal growth factor receptor; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1866989

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (155)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (23)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (132)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (182)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (496)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (460)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (77)
BioAssays deposited by other experimentalists

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