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Antagonist activity at SRA in RM1-OVA tumor bearing wild type C57BL/6 mouse derived CD11bpositiveLy6ChighLy6Gnegative myeloid-derived suppressive cells co-cultured with splenocytes assessed as reduction in protein-mediated inhibition of anti CD3/CD28 antibody-induced T-cell proliferation at 10 to 20 uM preincubated for 2 hrs followed by splenocytes addition measured after 72 hrs by [3H]-thymidine incorporation assay
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at SRA in RM1-OVA tumor bearing wild type C57BL/6 mouse derived CD11bpositiveLy6ChighLy6Gnegative myeloid-derived suppressive cells co-cultured with splenocytes assessed as reduction in protein-mediated inhibition of anti CD3/CD28 antibody-induced T-cell activation by measuring IL-2 secretion at 10 to 20 uM pretreated for 2 hrs followed by splenocytes addition measured after 56 hrs by ELISA
Assay data:1 Active, 1 Tested
Antagonist activity at SRA in RM1-OVA tumor bearing wild type C57BL/6 mouse derived CD11bpositiveLy6ChighLy6Gnegative myeloid-derived suppressive cells co-cultured with splenocytes assessed as reduction in protein-mediated inhibition of anti CD3/CD28 antibody-induced T-cell activation by measuring IL-2 secretion pretreated for 2 hrs followed by splenocytes addition measured after 56 hrs by ELISA
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse recombinant SRA extracellular domain expressed in baculovirus infected Sf21 insect cells assessed as inhibition of protein-induced reduction of IL2 gene promoter activation in anti CD3/CD28 antibody activated wild type C57BL/6 mouse B3Z T-cells at 50 uM after 5 hrs by beta-galactosidase reporter gene assay
Assay data:2 Active, 3 Tested
Inhibition of scavenger receptor A in mouse DC1.2 cells assessed as decrease in poly(I:C)-induced activation of STAT1 pretreated for 2 hrs before poly(I:C) stimulation measured after 3 hrs by immunoblotting
Inhibition of scavenger receptor A in mouse DC1.2 cells assessed as decrease in poly(I:C)-induced activation of IRF3 pretreated for 2 hrs before poly(I:C) stimulation measured after 3 hrs by immunoblotting
Inhibition of scavenger receptor A in wild type C57BL/6 mouse BMDC assessed as OVA257-264 peptide-induced T cell activation by measuring IL2 production at 30 uM after 56 hrs by ELISA
Inhibition of scavenger receptor A in wild type C57BL/6 mouse BMDC assessed as OVA257-264 peptide-induced T cell activation by measuring IL2 production at 10 uM after 56 hrs by ELISA
Inhibition of scavenger receptor A in wild type C57BL/6 mouse BMDC assessed as gp100 (25 to 33) peptide-induced T cell activation by measuring IL2 production at 20 uM after 56 hrs by ELISA
Assay data:2 Active, 2 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibitory activity against [125I]acetyl-LDL binding to mouse peritoneal macrophage scavenger receptor at 30 uM
Inhibitory activity against [125I]-acetyl-LDL binding to mouse peritoneal macrophage scavenger receptor at 100 uM
Inhibitory activity against [125I]acetyl-LDL binding to mouse peritoneal macrophage scavenger receptor at 10 uM
Activity against acetyl-LDLbinding to scavenger receptor as percent inhibition of incorporation of DiI-acetyl-LDL into mouse peritoneal macrophages at 30 uM; NT denotes not tested
Assay data:7 Tested
Activity against acetyl-LDLbinding to scavenger receptor as percent inhibition of incorporation of DiI-acetyl-LDL into mouse peritoneal macrophages at 30 uM
Assay data:6 Tested
Percent inhibition of DiI-acetyl-LDL binding to scavenger receptor of mouse peritoneal macrophages at 100 uM
Assay data:13 Tested
Activity against acetyl-LDLbinding to scavenger receptor as percent inhibition of incorporation of DiI-acetyl-LDL into mouse peritoneal macrophages at 10 uM; NT denotes not tested
Assay data:10 Tested
Activity against acetyl-LDLbinding to scavenger receptor as percent inhibition of incorporation of DiI-acetyl-LDL into mouse peritoneal macrophages at 10 uM
Assay data:3 Tested
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