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Inhibition of Nav1.8 in C57BL/6 mouse DRG neurons assessed as reduction in TTX resistant sodium channel-mediated currents up to >3000 nM at -60 mV holding potential by manual patch clamp electrophysiology method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to mouse Nav1.8 TTX-resistant current by radioligand binding assay
Assay data:2 Tested
Inhibition of NaV1.8 in C57BL/6 mouse DRG neurons assessed as reduction in tetrodotoxin-sensitive sodium channel currents at holding potential of -140 mV by manual patch clamp electrophysiology assay
Inhibition of Nav1.8 in mouse DRG neurons assessed as inhibition of TTX-resistant current at 10 uM at holding potential of -120 mV by manual patch electrophysiology method
SummaryRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assay
Assay data:20 Active, 13 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse NaV1.8 by electrophysiology
Assay data:24 Active, 19 Activity ≤ 1 µM, 25 Tested
Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assay
Assay data:8 Active, 2 Activity ≤ 1 µM, 10 Tested
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay
Assay data:23 Active, 8 Activity ≤ 1 µM, 27 Tested
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