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Induction of calstabin-2 binding to PKA-phosphorylated RyR1 in mouse skeletal muscle at >50 nM
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Induction of calstabin-1 binding to PKA-phosphorylated RyR1 in mouse skeletal muscle at >50 nM
Induction of calstabin-2 binding to RyR1 in mouse skeletal muscle at >50 nM
Induction of calstabin-1 binding to RYR1 in myocardial infarction-induced heart failure calsiabin2-/- mouse soleus muscle at 0.5 mg/kg/day dosed via implantable osmotic minipumps
Inhibition of of PKA-induced RyR1 phosphorylation in myocardial infarction-induced heart failure mouse soleus muscle at 0.5 mg/kg/day dosed via implantable osmotic minipumps
Induction of calstabin-1 binding to RYR1 in myocardial infarction-induced heart failure wild type mouse soleus muscle at 0.5 mg/kg/day dosed via implantable osmotic minipumps
Induction of calstabin-1 binding to RyR1 in mouse skeletal muscle at >50 nM
Normalization of RYR1 in myocardial infarction-induced heart failure mouse soleus muscle assessed as decrease in average channel close dwell time
Assay data:1 Tested
SummaryRelated BioAssays by Target
Normalization of RYR1 in myocardial infarction-induced heart failure mouse soleus muscle assessed as increase in average channel open dwell time
Induction of normalization of RYR1 function in mdx dystrophin deficient mouse soleus muscle assessed as decrease in average channel close dwell time at 1 uM
Induction of normalization of RYR1 function in mdx dystrophin deficient mouse soleus muscle assessed as increase in average channel open dwell time at 1 uM
Induction of normalization of RYR1 function in mdx dystrophin deficient mouse soleus muscle assessed as increase in channel open probability at 1 uM
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Activation of ryanodine receptor 1 in mouse C2C12 cells assessed as induction of calcium mobilization
SummaryPubMed CitationRelated BioAssays by Target
Selective inhibition of Ryanodine receptor 1 mediated physiological [Ca2+] release (PCR) from sarcoplasmic reticulum against calcium-induced Ca2+ release (CICR)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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