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Inhibition of Rac1 activation in mouse NIH/3T3 cells lysates pre-incubated for 1 hr before addition of Rac activator stimulation by immunoblot analysis based pull-down assay relative to control
Assay data:10 Active, 8 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Rac1 in mouse airways smooth muscle cells assessed as reduction in methacholine-induced maximal contraction pre-incubated for 1 hrs before methacholine addition
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of Rac1 in mouse NIH/3T3 cells assessed as reduction in Rac activator-stimulated cell migration incubated for 24 hrs
Assay data:2 Active, 2 Tested
Inhibition of Rac1 in mouse NIH/3T3 cells assessed as reduction in Rac activator-stimulated cell adhesion measured every 5 mins for 6 hrs by xCELLigence assay
Inhibition of Rac1 in mouse NIH/3T3 cells assessed as reduction in Rac activator-stimulated membrane ruffling
Assay data:2 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to mouse Rac1 in presence of EDTA by SPR assay
Binding affinity to mouse Rac1 by SPR assay
Inhibition of Rac1 activation in mouse NIH/3T3 cells lysates pre-incubated for 1 hr before addition of Rac activator stimulation by immunoblot analysis based pull-down assay
Inhibition of mouse Rac1 assessed as decrease in B-max for GTP-binding on Rac1 by mant-GTP binding kinetics real-time assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
TLR-pathway-mouse_LPS ligand_TNF readout
Assay data:130 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
TLR-pathway-mouse_P3C ligand_TNF readout
Assay data:115 Active, 756 Tested
TLR-pathway-mouse_LPS ligand_NFkB readout
Assay data:137 Active, 756 Tested
TLR-pathway-mouse_R848 ligand_NFkB readout
Assay data:147 Active, 756 Tested
TLR-pathway-mouse_R848 ligand_TNF readout
TLR-pathway-mouse_P3C ligand_NFkB readout
Assay data:128 Active, 756 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of PDGF-BB-stimulated Rac1-mediated cellular events in mouse 3T3 cells assessed as induction of membrane ruffling formation at 25 uM after 48 hrs by fluorescent microscopy
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PDGF-BB-stimulated Rac1-mediated cellular events in mouse 3T3 cells assessed as induction of membrane lamillipodia at 25 uM after 48 hrs by fluorescent microscopy
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