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Bayer inhouse assay (mouse)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assay
Antagonist activity at FPR in mouse NIH3T3 cells co-transfected with mtClytin assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 5 mins followed by PGF2alpha stimulation and measured for 60 secs by calcium dye based fluorescence assay
Allosteric modulator activity at prostaglandin F2alpha receptor in CD-1 mouse myometrial strips assessed as inhibition of PGF2alpha- induced contraction at 10 uM pre-incubated for 20 mins followed by PGF2alpha challenge
Assay data:6 Active, 35 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Allosteric modulator activity at prostaglandin F2alpha receptor in CD-1 mouse myometrial strips assessed as inhibition of PGF2alpha- induced contraction at 1 uM pre-incubated for 20 mins followed by PGF2alpha challenge
Assay data:5 Active, 34 Tested
Mouse FP receptor (Prostanoid receptors)
Assay data:10 Active, 10 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of PGF2alpha-induced spasmogenic effect at 10'-3 M preincubated for 3 mins followed by PGF2alpha challenge relative to control
Assay data:4 Active, 4 Tested
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of KCl-induced spasmogenic effect at 10'-3 M preincubated for 3 mins followed by KCl challenge relative to control
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of acetylcholine-induced spasmogenic effect at 10'-3 M preincubated for 3 mins followed by acetylcholine challenge relative to control
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of KCl-induced spasmogenic effect preincubated for 3 mins followed by KCl challenge followed by compound washout
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of acetylcholine-induced spasmogenic effect preincubated for 3 mins followed by acetylcholine challenge followed by compound washout
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of KCl-induced spasmogenic effect at 3X10'-5 M preincubated for 3 mins followed by KCl challenge relative to control
Assay data:1 Tested
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of PGF2alpha-induced spasmogenic effect preincubated for 3 mins followed by PGF2alpha challenge followed by compound washout
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of acetylcholine-induced spasmogenic effect at 3X10'-5 M preincubated for 3 mins followed by acetylcholine challenge relative to control
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of PGF2alpha-induced spasmogenic effect at 3X10'-5 M preincubated for 3 mins followed by PGF2alpha challenge relative to control
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of acetylcholine-induced spasmogenic effect at 5X10'-5 M preincubated for 3 mins followed by acetylcholine challenge relative to control
Antagonist activity at prostaglandin F2-alpha receptor in isolated Albino mouse ileum assessed as inhibition of KCl-induced spasmogenic effect at 5X10'-5 M preincubated for 3 mins followed by KCl challenge relative to control
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