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dUTPase Inhibition from US Patent US10858344: "Hydantoin containing deoxyuridine triphosphatase inhibitors"
Assay data:13 Active, 2 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US8883759: "Anti-tumor effect potentiator"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
Inhibition Assay from US Patent US8530490: "Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity"
Assay data:139 Active, 89 Activity ≤ 1 µM, 141 Tested
Inhibition Assay from Article 10.1080/14756360801915476: "Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni."
Assay data:5 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to DUT in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of recombinant human dUTPase expressed in Escherichia coli BL21 (DE3) using dUTP as substrate by spectrophotometric analysis
Assay data:1 Active, 14 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Break-induced replication repair of damaged forks induces genomic duplications in human cells
Assay data:478 Active, 1380 Tested
Inhibition of dUTPase in human HeLa S3 cells assessed as potentiation of 1 uM FdUrd-induced decrease in cell density incubated for 48 hrs by crystal violet assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human dUTPase assessed as reduction in [5-3H]dUMP production incubated for 15 mins by HPLC
Assay data:22 Active, 19 Activity ≤ 1 µM, 28 Tested
Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells after 72 hrs by crystal violet staining
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human dUTPase-mediated cell proliferation in HeLa S3 cells assessed as compound concentration required to reduce 50% of 1 uM of FdUrd T/C after 24 hrs by crystal violet staining
Assay data:17 Active, 13 Activity ≤ 1 µM, 17 Tested
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